|
|
|
|
|
Compound Profiling |
|
|
|
Pharmacology profiling is an invaluable tool for lead compound screening, optimization and candidate prioritization. Analysis of compound profile data identifies off-target interactions that can help predict potential side-effects and safety issues of compounds under development before they progress to the more costly stages of preclinical and clinical trials. HDB offers comprehensive profiling services to meet our clients' drug |
discovery & development needs. |
|
Our compound profiling service include: |
|
GPCRs |
• |
|
Panels of 20, 30, 60 GPCRs for selectivity screening |
• |
|
Cell-based functional assays, membrane prep binding assays or GTPγS binding assays |
|
|
Enzymes |
• |
|
Kinase selectivity (panels of 20-, 40-, 60-kinases ) |
• |
|
Enzyme assays or SPA/radiometric assays |
|
|
ADME |
• |
|
Solubility |
• |
|
Plasma protein binding |
• |
|
Metabolic stability |
• |
|
Permeability (Caco-2) |
• |
|
CYPs inhibition |
• |
|
Human CYP3A4 induction cell based assay |
• |
|
Human CYP1A induction cell based assay |
• |
|
P-gp inhibition cell based assay |
|
|
In vitro Toxicity |
• |
|
hERG assay (patch-clamp; binding assays) |
• |
|
Ames test, micronucleus test |
• |
|
Hepatotoxicity |
• |
|
Cytotoxic ATP depletion assay |
• |
|
Mitochondria toxicity |
|
|
Functional Cell-based Assays |
• |
|
High content assays |
• |
|
Phenotypic cellular assays |
|
|
|
|
|
|
|
|
|
|
 |
|
|
The Latest Generation of Auto Patch Clamp Platform Launched at HDB  |
|
---------------------- |
WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation" |
|
---------------------- |
HD Biosciences Merges with WuXi AppTec |
|
|
|
|
|
|
|
|
|
|
沪公网安备 31011502003320号