|
|
|
|
Plate-based Pharmacology |
|
As a global leader in plate based pharmacology R&D services, HD Biosciences provides the best in class of the supports to our clients in their efforts on preclinical drug discoveries, from assays & assay development, hit identification, hit-to-lead, lead optimization, to candidate selection. Resourceful assets in assays, cell lines collections in major target classes, such as GPCRs, kinases & other enzymes, ion channels and transporters, offer a broad range of formats and matching screening capabilities. The fully implemented industry compliant processes that rank the highest among Chinese CROs by our clients, make HD Biosciences as a partner to |
choose for your plate-based pharmacology needs. |
|
Our screening capabilities span from cell line generation, biochemical and cell-based assays, high throughput screening, SAR screening, high content, multiplex to primary cells/tissues in a variety of technology platforms. Comprehensive infrastructure with instrumentation, proprietary data/compound management system and IT support with e-notebook option, provides a precise capture of information flow from compound, assay/screen, |
to data management. |
|
Currently HDB’s mature plate-based platforms are capable to support in multi-clients, multi-projects at multi-formats in parallel. The yearly throughput for screening data point has exceeded 10 millions. Our operation |
back-up plan ensures the continuation of the processes and deliveries without hiccup. |
|
|
|
|
Assay Platform |
|
HTS and Hit Identification |
|
Lead Discovery |
|
|
|
|
Biochemical and cell-based assays |
Primary screening
|
Secondary screening
|
|
|
|
Radiometric & binding assays |
Cherry picking and hit confirmation
|
SAR screening (Hit Triage) |
|
|
|
Report gene assays |
IC50/EC 50 determination
|
Compound profiling
|
|
|
|
Micro-fluid kinetics (Caliper),
|
Hit follow-up |
Counter screening & off target selectivity
|
|
|
|
Protein-protein interaction, substrate-enzyme |
Compound QC (LC/MS based) |
Early compound safety prediction |
|
|
|
kinetics (BiaCore), |
|
ADME screens |
|
Infrastructure |
|
LC/MS/MS-based assays |
|
|
Phenotypic & functional assays |
Designated HTS & SAR screen central labs |
|
|
High content assays & multiplexing assays |
Compound storages accommodating over 3 |
|
|
Functional GPCR & nuclear receptor assays |
million compounds |
|
|
Enzymes assays (kinase, protease, PDEs, HDAC, etc.) |
Proprietary compound management database |
|
|
Ion channels and transporters |
Activity Base and other tools |
|
|
Custom assay development |
E-notebook |
|
|
|
|
|
|