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High-throughput arrayed screening in both 96 and 384 well microplates |
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For cell based assays in target validation, hit identification, biomarker discovery and mechanism of action studies |
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Supporting customized immunology assays using primary immune cells |
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Supporting functional genomics screening on CRISPR KO, CRISPRi and CRISPRa |
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iQue PLUS HTFC Platform |
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HD Biosciences (HDB) newly implemented iQue Screener Plus high-throughput flow cytometry (HTFC) system, the next-generation technology with exciting features of high-throughput and miniaturization, significantly enhances the capability to meet the demands |
of pre-clinical drug discovery and translational applications in clinical practice. |
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The ability to perform multiplex and high-content measurements of this system has made flow cytometry a powerful tool used for deep science and pharmacology exploration. The overcome of issue on lower throughput from traditional flow cytometry makes screening assays possible. HDB HTFC system is capable of running multiplexed screening assays at both 96- and 384-well plates, provides value information for your R&D portfolio with |
efficiency. |
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High throughput, multiplex with sample miniaturization: |
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Three lasers (VBR), detect 13 channels simultaneously |
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Compatible with 96-well or 384-well formats |
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Process 96-well and 384-well plates from 6 and 20 min |
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Sample volume as low as 15µl, saving precious samples, reagents, and reduce costs |
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Fig.1: Revolutionary rapid sampling method guarantees highest assay speed to reduce time and cost. |
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An integrated flow cytometry system |
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The iQue Screener PLUS platform is an integrated system with analysis software, hardware and reagent system that enables rapid, high content, multiplexed analysis of cells and beads in suspension, profiles, functionally characterizes events relevant to hit |
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identification, drug MOA and disease diagnoses. |
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Fig.2: A built-in software to conduct real-time data analysis and perform multiple display and statistics modes. |
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Powerful tool for pre-clinical and clinical campaign |
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Next generation HTFC platform to identify hits from compound screening assays. |
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Hit identification at target based or phenotypic based screening |
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Drug effects on cell cycle, proliferation and apoptosis |
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Beads-based profiling to characterize cytokines secreted from primary cells or clinical samples including PBMCs |
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Cellular biomarkers for potential drug targets, clinical diagnoses and prognoses |
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Capable to handle large number of samples with efficiency |
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Fig3: High throughput screen of a 1.4k compound library for apoptosis induction. Effect of compound for caspase 3/7 activation (A), annexin V (B), cell viability (C) were showed above. Blue dot indicate Max response induced by Staurosporine and light green dot indicate Min response induced by DMSO. |
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Fig4: iQue specified non-wash beads-based kit is able to provide effective and efficient cytokine and biomarker screening assays. |
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Related Services |
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