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TPA-topical |
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| Model: |
Phorbol ester induced ear edema model in ICR or Balb/c mice |
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| Animal: |
ICR mice |
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| Inducer: |
TPA |
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| Study duration: |
Acute model: one day; chronic model: 10 days (in life) |
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| Pathological features: |
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Ear edema is the primary response |
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Acute model: Non-T cell mediated response, involves TNFa, COX and LOX |
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pathway |
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Chronic model: More inflammatory cells involved; epidermal hyperplasia |
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| Suitability: |
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Acute model: Drug screening |
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Chronic model: |
More relavant (test compounds are applied after the |
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inflammatory lesion is established) |
| More selective |
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| Parameter measures: |
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Ear thickness (edema) |
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Histo-pathology assessment |
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Ear weight |
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IHC |
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cytokine (ELISA or RT-qPCR, optional) |
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The Latest Generation of Auto Patch Clamp Platform Launched at HDB  |
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WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation" |
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HD Biosciences Merges with WuXi AppTec |
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