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Mitochondrial Toxicity -
Isolated rat liver mitochondrial (RST/OCR) assay |
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Mitochondrial dysfunction is a major contributor to drug-induced toxicity, post-market drug withdrawal and black box warnings for hepatic and cardiac toxicity. Considering the mitochondria play such a pivotal role in cellular energy (ATP) production homeostasis, evidence now supports a growing industry trend to early screening |
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for mitochondrial toxicity in drug discovery. |
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HDB Biosciences (HDB), in alliance with Luxel Biosciences, offers a novel mitochondrial toxicity assay using the Respirometric Screening Technology (RST), a technology originally developed by Luxcel and Pfizer1,2,3, which now has been widely utilized by pharmaceutical and biotech companies. (Ref: 1)Nature Protocols 1(6):2563-72(2006); 2)Toxicology in Vitro |
27(2013),560-569; 3)Expert Opin. Drug Metab. Toxicol. (2014)) |
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The RST assay features: |
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An ex-vivo system using freshly isolated rat liver mitochondria |
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Measures oxygen consumption rate (OCR) using the MitoXpress® oxygen-sensing probe |
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Significant advantage compared to Glu/Gal, RST/OCR assay differentiates specific |
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mitochondrial vs. non-specific toxicity, and uncoupler vs. inhibitor |
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Fully validated assay in high throughput format |
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Identify mitochondrial liabilities in a variety of drug classes leading to broad industry |
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adoption. |
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HDB is the sole service provider of the RST assay globally and is the designated partner for |
a big pharmaceutical company on drug safety profiling! |
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Please download our brochure for more assay information and validation data. |
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Mitochondrial |
Toxicity Assay |
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Reference: |
1. Nature Protocols 1(6):2563-72(2006); |
2. Toxicology in Vitro 27(2013),560-569; |
3. Expert Opin. Drug Metab. Toxicol. (2014). |
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Related Services |
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| Toxicology Service |
| In vitro Safety Pharmacology Profiling |
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