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Biochemical and cellular assays |
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Biophysics assays for kinetics/affinity characterization |
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Various assay formats with capability to run both end-point and real-time kinetic analysis in high throughput format |
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HD Biosciences' reputable in vitro pharmacology platforms, synergized with WuXi AppTec powerful chemistry platform and featured with structural biology platform from CRELUX, |
provide comprehensive solutions supporting TPD drug R&D. |
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Binary/Ternary Complex Formation Assay Platform |
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Biochemical/Biophysics assays |
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Binary/ternary binding assays at formats on TR-FRET, AlphaScreen, Fluorescence Polarization (FP), radioactive assays, etc. |
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Biophysics approach with SPR (Biacore 8K+) and thermo shift assays |
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SPR assay measures the kinetics of binary/ternary complex formation and provides rationale for preferred-ternary-complex-formation in TPD design and optimization. |
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Representative data for SPR Assay |
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Cellular assays |
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Target-E3 ligase PPI assay (NanoBRET) |
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NanoBRET cellular PPI assay evaluates target-E3 complex formation at desirable expression level and compatible with both end-point and real-time kinetic analysis |
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Target/E3 engagement assay (NanoBRET) |
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Target Ubiquitination & Degradation Assay Platform |
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Biochemical assays |
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Target ubiquitination assay (TR-FRET, AlphaScreen) |
Cellular assays |
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Target ubiquitination assay (NanoBRET) |
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Target recruitment to proteasome assays (NanoBRET) |
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Target degradation assay (HiBiT, AlphaLISA, TR-FRET, ELISA,) |
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HiBiT cellular assay enables monitoring of target protein degradation at |
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physiological level and provides both end-point and kinetic detections |
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To receive more information on HDB TPD service, please contact us. |
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The Latest Generation of Auto Patch Clamp Platform Launched at HDB  |
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WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation" |
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HD Biosciences Merges with WuXi AppTec |
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong,
Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
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