Hyperinsulinemic euglycemic clamp is the gold standard for investigating and quantifying insulin resistance. This technique is widely used in clinics and laboratories to measure insulin action on glucose utilization in humans and animals for clinical and basic science research. Low-dose insulin infusions are more useful for assessing the response of the liver, whereas high-dose insulin infusions are useful for assessing peripheral (i.e., muscle and fat) insulin action. Incorporation of radioactive-labeled glucose during euglycemic clamps makes it possible to measure glucose metabolism in individual organs. In HDB, the mature clamp technique have been validated and actively performed in animal models of obesity, diabetes, and its complications. The study design could be tailored for our clients' specific requirements.