HD Biosciences offers high-quality, and cost-effective screening services that cover from biochemical, radiometric, cell-based, to high content, multiplex, LC/MS based screening for the hit identification and lead discovery. Our State of the Art screening center is capable of
producing over 100,000 data points per day, per individual primary screening.
For years, HD Biosciences has an excellent track record in HTS services. We are the designated “The Center of the Excellence in Hit Identification and Lead Discovery” for several global pharmaceutical companies and support their company-wide needs in
screening activities.
In addition to high throughput screening services, HD Biosciences also offer the compound management supports for the partners/clients. The company currently handles the size of over 3 million compounds in single and/or compressed formats, both dry and DMSO, for several clients to support daily screening activities, as well as global compound distribution. Besides client’s compounds for screening activities, HD Biosciences proprietary diversified TCM-based natural product library with over 10,000 HPLC-
fractionated samples, is also available for custom screening services.
Integrated Screening Platform
Compound Management
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Designated & secured storage for individual HTS/SAR project for each client
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SOP enforced process to support compound receiving, registration and storage with 2D
barcode option
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Experience of handling over 3 million compounds under varieties of formats for multiple
clients (RAMP plates, dry, DMSO)
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Proprietary compound data management system (CPMS) to provide solutions for t
information tracking from vials/plates, assay/screening, to data processing/output and
managemen
Assay Development/Transfer & Screening
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Designated POC for individual program on assay development, optimization and
validation
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Expertise in assay adaptation to HTS for seamless assay-HTS transfer and operation
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On site, real time checking for screening QA/QC
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Varieties of assay and screen formats to address unmet needs
Data Management & IT Support
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CPMS and other database tools to capture precise information flow
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Strong IT Infrastructure with variety of data analysis tools to facilitate data recording,
curve fitting, visualization and reporting
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VPN and e-notebook available for secured data sharing and transfer
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Designated POC for secured data review and assurance of data integrity
Project Management & Quality Assurance Support
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Project Management & Quality Assurance Support
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Final data quality assurance with notebook archiving and compliance
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Close communication with clients for transparent operation & progress update
HTS and SAR Screening Workflow
Quality Control and Assurance
Equipment Regular QC & Calibration
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All equipment were professionally calibrated regularly and before
each campaign
Data QC - NIH Guidance & Beyond
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Cross-day, cross-plate tests of SW, EC/IC50 & the rank order of
potencies of reference compounds with acceptable variations
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ZPE, HPE, MSR and Z’ factor tests in three separate experiments
in assay validation phase
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Reference compounds with multiple concentrations imbedding in
individual screening campaign
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Z factor summary for every primary screening
Compound QC
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Compound QC for HTS selected hits to eliminate mismatched
biological and chemical data
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Data analysis result reported within 24h after screening result
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UPLC/MS based analysis with a throughput > 3,000 compounds
per week
Primary HTS, Hit Confirmation and Hit Follow-up
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470,000+ compounds library screened on a Amplex red/HRP based fluorescence assay
on Envision
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Hit rate: 2.1% (threshold: 30% inhibition)
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Hit confirmation rate: 75.58%
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Plate failure rate: < 3%
The Latest Generation of Auto Patch Clamp Platform Launched at HDB
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WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation"
The Latest Generation of Auto Patch Clamp Platform Launched at HDB
We are excited to announce the installation and operation of SyncroPatch 384, the latest generation of automated patch clamp (APC) system which can be implemented into all phases of drug discovery.
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WuXi Biology/HD Biosciences Presented at webinar of "New Technologies for Target Discovery and Validation"
Novel target discovery and validation are the most crucial steps and prerequisites for successful drug development.
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HD Biosciences Merges with WuXi AppTec
HD Biosciences Co., Ltd. (HDB), a leading biology-focused preclinical drug discovery contract research organization (CRO), today announces its merge with WuXi AppTec, a leading global pharmaceutical, biotechnology and medical device open-access capability and technology platform.
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