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EAE-MBP
Model: Myelin Basic Protein (MBP) induced EAE in Lewis rats - acute model
Animal: Lewis rat
Immunogen: Guinea pig derived myelin basic protein (MBP)
Study duration: 22 days (in life)
Pathological features:
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Acute EAE model mimic exacerbation in clinic (single relapse and self-limiting)
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Infiltration of mononuclear cells/T cells and foci formation in CNS
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De-myelination rarely observed
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Antibody response delayed usually after remission
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Reliable and reproducible
Suitability:
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Compound screen
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Efficacy study
Parameter measures:
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Body weight
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clinical score
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Histo-pathological assessment
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Cytokine ELISA (optional)
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RT-qPCR (optional)
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IHC (optional)
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