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Diabetes & Diabetic Complications |
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HDB is the premier provider for high quality services of diabetes mellitus research, with enormous experiences in studies performed for biopharmaceutical companies of all sizes and availability of most predictive disease models developed either spontaneously or induced by dietary and/or chemicals. Models of diabetic complications are offered for ophthalmologic diseases, wound healing, neuropathic pain and nephropathy. The animal species covers mouse, rat, guinea pig and rhesus monkey. The recently developed molecular biological capability for transgenic mouse breeding highlights HDB's |
unparalleled professional expertise and dedication in drug discovery of diabetes field. |
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Our experimental approaches include routine glucose monitoring, biomarker quantification (insulin, GLP-1, GIP, glucagon…), glucose tolerance test (OGTT, IPGTT, IVGTT), insulin tolerance test (ITT), metabolic phenotyping (body weight, food intake, water consumption, urine, energy expenditure, locomotion, body composition), pair-fed manipulation, gastric emptying, hyperinsulinemic-euglycemic clamp, intestinal bacteria |
profiling, and histological/morphological examinations etc. |
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HDB difference in metabolic disease service comprises the seasoned experise team, standarized experiementation performances, skillful manipulations in solving key issues, consensus recommendations on choices of appropriate tests, and correct scientific |
interpretations to guide subsequent studies. |
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Fig. 1 Compound evaluation in animal models of spontaneous diabetes (db/db mice). The endpoints include body weight change (A), blood glucose (B), plasma insulin (C) and b cell mass (D). |
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Fig. 2 Effects of test compound on islet structure preservation was evaluated in animal models of spontaneous diabetes (db/db mice) by immunohistochemistry (IHC) method. |
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Fig. 3 OGTT screening in male C57BL/6 mouse. Tested animals were orally challenged with 2 g/kg D-glucose, and the compound efficacy was evaluated on glucose excusion (A), AUC (B), insulin secretion (C). The incretin response in OGTT was determined by total plasma GLP-1 level (D) and total plasma GIP (E) as well. |
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Fig. 4 Visualization of retinal vessel leakage by Evans Blue (EB) perfusion and fluorescence examination of retinal sections. Intra-vitreal injeciton of VEGF induced predominant retina vascular leakage in Sprague-Dawley (SD) rats. |
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The Latest Generation of Auto Patch Clamp Platform Launched at HDB  |
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WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation" |
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HD Biosciences Merges with WuXi AppTec |
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