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Arthritis (mice) |
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| Model: |
Collagen type II induced arhtritis in mice (CIA) |
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| Animal: |
DBA/1 |
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| Immunogen: |
type II collagen (chicken) |
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| Study duration: |
8-9 weeks (in life) |
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| Pathological features: |
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Slower onset |
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Synovitis, pannus formation, cartilage damage and bone erosion |
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High levels of anti-CII antibody production |
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Mononuclear cell infiltration, synovial hyperplasia and marginal |
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erosion are similar to AIA and human RA |
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| Suitability: |
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Drug development |
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| Parameter measures: |
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Body weight |
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clinical score |
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Hind paw swelling |
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X-ray examination |
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Histo-pathological examination |
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cytokine (optional) |
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ctrl: normal synovial lining |
CIA: Bone/cartilage erosion and inflammatory infiltration |
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CIA: cellular infiltration in synovial lining |
CIA: Muscle damage and synovial hyperplasia |
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The Latest Generation of Auto Patch Clamp Platform Launched at HDB  |
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WuXi Biology/HD Biosciences Presented at Webinar of "New Technologies for Target Discovery and Validation" |
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HD Biosciences Merges with WuXi AppTec |
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