|
Target validation &
target engagement |
|
In vitro assays for
Hit ID |
|
Functional &
phenotypic assays |
|
Glucose uptake |
|
Fatty acid oxidation |
|
Insulin secretion
in islets (GSIS) |
|
Lipogenesis & lipolysis |
|
Insulin signaling
pathway |
|
Multiplexing profiling with MSD panels (metabolic markers) |
|
Disease models |
|
Obesity |
|
Dyslipidemia |
|
|
|
Target validation |
|
Tumor cell panel & screening |
|
Cell proliferation & cell cycle |
|
Cell invasion & migration
|
|
3-D cell based assay |
|
Cell signaling pathway & MOA |
|
Cancer metabolism |
|
In vivo tumor models |
|
Xenograft models |
|
Orthotopic models |
|
Stem cell tumor models |
|
Metastasis models |
|
Predictive biomarkers and companion diagnostics |
|
TCPD(Tumor Cell Panel Database) |
|
|
|
In vitro Neurosciences |
|
Anxiety including PTSD model |
|
|
|
Cell based phenotypic assay |
|
Cytokine & chemokine measurement |
|
T cell & B cell proliferation assay |
|
Chemotaxis assay |
|
Animal models |
|
Experimental allergic encephalomyelitis (EAE) |
|
Asthma model |
|
Lung inflammation/fibrosis |
|
Rheumatoid arthritis |
|
Skin inflammation |
|
Inflammatory Bowel Disease (IBD) |
|
Passive Cutaneous Anaphylaxis (PCA) |
|
MSU Induced Inflammatory Gout |
|
Carrageenan induced air pouch model |
|
|
| |
Fibrosis Diseases |
| |
Liver fibrosis |
|
Biomarkers analysis |
|
Cell-based assays |
|
Animal models |
|
CCl4 model |
|
BDL model |
|
|
|
Dermatology |
|
|
|
Anti-viral assay |
|
HCV |
|
RSV |
|
HBV |
|
Influenza |
|
Anti-bacteria assay |
|
MIC test |
|
Time Kill study |
|
Post-antibiotic-effect (PAE) study |
|
Checkerboard assay |
|
Macromolecule synthesis pathway study |
|
Resistant test |
|
Nephrotoxicity assay |
|
|
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