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Compound Profiling

Pharmacology profiling is an invaluable tool for lead compound screening, optimization and candidate prioritization. Analysis of compound profile data identifies off-target interactions that can help predict potential side-effects and safety issues of compounds under development before they progress to the more costly stages of preclinical and clinical trials. HDB offers comprehensive profiling services to meet our clients¡¯ drug discovery & development needs.

Our compound profiling service include:

GPCRs
Panels of 20, 30, 60 GPCRs for selectivity screening
Cell-based functional assays, membrane prep binding assays or GTP¦ÃS binding assays
Enzymes
Kinase selectivity (panels of 20-, 40-, 60-kinases )
Enzyme assays or SPA/radiometric assays
ADME
Solubility
Plasma protein binding
Metabolic stability
Permeability (Caco-2)
CYPs inhibition
Human CYP3A4 induction cell based assay
Human CYP1A induction cell based assay
P-gp inhibition cell based assay
In vitro Toxicity
hERG assay (patch-clamp; binding assays)
Ames test, micronucleus test
Hepatotoxicity
Cytotoxic ATP depletion assay
Mitochondria toxicity
Functional Cell-based Assays
High content assays
Phenotypic cellular assays
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: (+86) 21-51163700
Fax: (+86) 21-51163766
operation@hdbiosciences.com