Epigenetics is one of the emerging fields which have the potential to explain mechanisms of aging, human development, the origins of cancer, heart disease, mental illness, as well as several other diseases. The molecular basis of epigenetics includes both DNA modification and Histone modification. Histone modification (particularly N-terminal of the histones) is the major process for regulating eukaryotic gene expression. It includes histone actylation, phosphorylation, methylation and ubiquitination. The combination of different histone modifications results in either active DNA conformation or repressive DNA conformation which subsequently leads to the activation or repression of certain gene expression. Overall, the property of epigenetic enzymes make them important targets in drug development.

HD Biosciences offers comprehensive epigenetic solutions and services from assay development to high throughput screening (HTS) for histone methyltrasnferase, histone demethylase, histone acetylase and histone deacetylase.