Chronic liver diseases including hepatitis and liver fibrosis are common diseases and the leading cause of death worldwide. HD Biosciences is experienced with development of animal models of chronic liver diseases including liver fibrosis/cirrhosis induced by hepatotoxins, alcohol or surgical obstruction of common bile duct in rodents. Antifibrotic effects are indicated by reduction of hydroxyproline, improvement of portal pressure, reduction of splenomegaly, and inhibition of collagen synthesis.