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Histopathology Services
Recognized for our breadth of capabilities and professional expertise in in vivo pharmacology and biomarker discovery, HDB merges our talents in histopathology to provide an advanced support to preclinical drug discovery. We provide services in histology, toxicological pathology, and disease pathology such as oncology, inflammation, metabolic diseases and neurodegeneration with extensive and comprehensive technology and expertise and pathology evaluation. The pathology team headed by a well experienced pathologist at HDB offers a wide range of preclinical histology and pathology services spanning all aspects of paraffin and frozen slide preparation, staining, and evaluation at the designated histology labs and closely works with our clients to assure the highest quality on our histopathology studies. This combination of experience and space
affords excellent capacity and throughput to meet clients' timelines.
Capability Overview
Histology laboratory capability
Tissus banks of rodent, rabbit, dog
Special histochemistry
monkey and human
Immunohistochemistry
Interpretation via board-certified
Disease pathology
pathologists and slide review over
Toxicologic pathology
th internet
Histomorphometry
Histopathology lab skills
Small and large animal necropsy
In-situ perfusion fixation
Ex-vivo organ perfusion fixation
Micro-dissection
High resolution gross necropsy photography
Regular H&E staining
Special staining: PAS, Masson trichrome, Silver, PAM, Sirius red, Oil red Sudan III and
other requested special staining
Immunohistochemical staining (IHC)
Immunofluorescent staining (IF)
Immunocytochemical staining (ICC)
In situ hybridization (ISH)
Fluorescent in situ hybridization (FISH)
Experimental pathological evaluation capabilities
Analysis for oncology study such as biomarker screen, location, density on cell lines,
CDX and PDX models, tissue microarray (TMA), cell line microarray (CMA)
Analysis for inflammatory / immune disease models such as EAE model, IBD model,
lung fibrosis model, COPD model and CIA model
Analysis for tissue and organ injuries such as stroke, AMI, kidney diseases, pain, CNS
diseases
Analysis for tissue and organ metabolic and degeneration such as liver diseases,
skeleton muscle degeneration, bone degeneration, connective tissue degeneration and
others
Toxicological pathology
Non-GLP toxic pathology including gross pathology and histopathology reading, analysis,
evaluation, review and report
Biomarker assay development and validation
Biomarker reorganization, localization, screening via IHC, FISH, ISH on TMA, CMA, human
tissue bank, animal tissue bank as well NHP tissue bank
Equipment and Facility
Organ perfusion tanks
Gross necropsy photography station
Light microscopes with digital photography
Automatic histoprocessor
Automatic stainer
Paraffin microtomes
Fluorescent microscopes with digital photography
Cryostat sectioning
-80 C degree tissue sample storage
Liquid nitrogen tissue sample storage
Regular paraffin embedded block sample storage
Biosafety hood
Figure 1: H&E and special staining for bone tissue histological analysis.
Figure 2: H&E, Sirius Red, Masson Trichrome, Oil Red O and IHC staining for liver tissue histological analysis.
Figure 3: Biomarkers detection with IHC at either in nucleus, cytoplasm or membrane of cancer cells and stroma.
Figure 4: Comparatives of IF and IHC double staining to identify the different biomarker location and expression in same cells. Detection of a biomarker X location and expression in -SMA positive stroma cells in colon cancer.
Figure 5: Cell line microarray (CMA) uses for the detection of P-cadherin location and expression in different breast cancer, colon cancer and bladder cancer cell line. Tissue microarray (TMA) uses for the detection of EGFR location and expression in 180 spots of different gastric cancer tissue and para cancer tissue.
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
info@hdbiosciences.com
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