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PDE Screening and Profiling |
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| As the important regulators of signal transduction mediated by second messenger molecules cAMP and cGMP, phosphodiesterases (PDEs) are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties. Using Caliper¡¯s LabChip platform, HDB provides high-quality screening and profiling services for PDE panel of 17 human PDEs. More PDE assays are under development. |
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HDB PDE Panel |
PDE1A |
PDE4D |
PDE1B |
PDE5A |
PDE1C |
PDE7A |
PDE2A |
PDE8A |
PDE3A |
PDE8B |
PDE3B |
PDE9A |
PDE4A |
PDE10A |
PDE4B |
PDE11A |
PDE4C |
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IC50 determination of dipyridamole against |
several PDEs using Caliper¡¯s LabChip |
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