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HD Biosciences and Luxcel Biosciences Enter Collaboration Agreement for Mitochondria Toxicity & Metabolism Assays for Preclinical Drug Safety Evaluation
Shanghai, China and Cork, Ireland
HD Biosciences Co., Ltd. (HDB), a leading biology-focused preclinical drug discovery contract research organization (CRO), and Luxcel Biosciences Ltd (Luxcel), a Cork based biotechnology company, announced today that they have entered a strategic partnership to co-market and provide new assay technologies for preclinical drug safety services. Under the agreement, HDB will gain access to Luxcel's state-of-the-art assays and
technologies for assessment of mitochondrial function, toxicity and metabolism.
Mitochondrial dysfunction is a major contributor to drug-induced toxicity, post-market drug withdrawal and black box warnings for hepatic and cardiac toxicity. A major focus of the collaboration is the Respirometric Screening Technology (RST/OCR) assay, originally developed by Luxcel in collaboration with Pfizer Inc. (Ref: Will, Y et al(2006) Nature Protocols). A significant advance of the RST assay, compared to the commonly used Glu/Gal assay, is its ability to accurately differentiate specific mitochondrial toxicity from non-specific toxicity, as well as uncouplers of mitochondrial function from inhibitors. The RST assay is now fully validated in high throughput format and in weekly production mode at HDB, Shanghai, providing clients with the best mitochondrial toxicity assay available
with a cost effective and quick turnaround service.
"We are delighted to team up with Luxcel Biosciences Ltd, a leader in the field of optical sensing technologies." "HDB offers a full range of in vitro toxicology services including safety profiling panels (SafetyAssess™), as well as cardiotoxicity, hepatotoxicity, genotoxicity and cytotoxicity screenings. Luxcel¡¯s growing portfolio of proprietary mitochondria toxicity, bioenergetics & metabolism assays, is highly complementary to our current offerings and will provide early and effective identification of mitochondrial liabilities for our client¡¯s drug discovery programs.¡± stated Dr. Peiyuan Lin, Senior VP of
R&D Services of HDB.
"HDB has established and maintained a professional reputation globally with its pre-clinical service, bringing their clients the most up to date and valuable assays and tools to advance the drug discovery process. This joint effort will leverage the extensive expertise and capabilities from both sides, for the benefit of global as well as China-based pharmaceutical and biotech companies." said Dr. Ian Hayes, Commercial Director for
Luxcel.
About HD Biosciences
HD Biosciences Co., Ltd. is a biology-focused preclinical drug discovery contract research organization (CRO) with headquarter in Shanghai, and operation facilities in Beijing and San Diego, USA. The company offers comprehensive research and development services to global pharmaceutical and biotech industries around target validation, plate-based pharmacology, hit identification & lead discovery, therapeutic antibody discovery, in vivo pharmacology, and other related areas. The company currently collaborates with eight (8) of the ten (10) largest pharmaceutical companies in the world and has established strategic partnerships with impacts to their portfolios. The strong scientific expertise, high quality of the services, consistency in deliveries, and constantly meeting or exceeding expectations, have helped the company to earn an excellent reputation in the industry. The in vitro pharmacology R&D and other core competencies of the company are widely recognized as one
of the best among preclinical CROs.
About Luxcel Biosciences Ltd:
Luxcel is an award winning, privately held Biotechnology company located in Co. Cork, Ireland. Luxcel develops state of the art optical sensing technologies, solutions and applications for a wide range of analytical and biological research and screening applications. Luxcel¡¯s assays and applications are based on proprietary optical sensing chemistries and methodologies, with a core expertise in the measurement of oxygen. Luxcel develops and commercializes a wide range of state of the kits and consumables to measure, for example cellular metabolism, mitochondrial (dys) function, toxicity and
cellular oxygenation. For more information see www.luxcel.com.
About RST/OCA Assay:
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
info@hdbiosciences.com
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