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SAR Driven Chemistry Services
With strong expertise and in-depth experience, we offer full range of medicinal chemistry services from hit identification, lead generation, lead optimization to preclinical candidate selection. Focused libraries and parallel synthesis provide fast solutions to hit identification and hit-to-lead generation. SAR exploration by the experienced medchem team and the biology counterpart offer advantages to achieve both efficiency and cost effectiveness. Intellectual inputs will be provided at every stage of the optimization
process to further enhance project's brainpower.
Hit identification
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Scaffold mining and designing
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IP analysis on designed scaffolds
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Structural diversity/uniqueness assessment
Lead generation
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Focused library and parallel synthesis
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Preliminary in vitro and in vivo DMPK screening
Lead optimization
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SAR generation and exploration
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in vitro and in vivo data evaluations
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Scale up to support key studies in animal models
Supporting clients' patent filings
Lab and facilities:
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State-of-the-art facility with well-equipped labs
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Robust analytic tools with open access LC-MS (Waters UPLC-MS) and NMR
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Efficient purification systems featured by semi-prep HPLCs (Gilson and Shimadzu) and ISCOs
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Convenient chemistry reference search tool (SciFinder/SciPlanner) to support innovative discovery research
Medicinal Chemistry Lab Medicinal Chemistry Lab
UPLC-MS Biotage Initiator Sixty
Gilson prep HPLC CombiFlash
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
info@hdbiosciences.com
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